Effect of peroxynitrite on erythrocytes.
Biochim Biophys Acta
; 1291(2): 107-14, 1996 Oct 24.
Article
em En
| MEDLINE
| ID: mdl-8898870
ABSTRACT
The action of peroxynitrite on human erythrocytes and erythrocyte membranes was studied. Peroxynitrite (0.1-2 mM) induced a transient decrease of intracellular reduced glutathione, oxidized membrane protein -SH groups, initiated membrane lipid peroxidation and inactivated erythrocyte membrane acetylcholinesterase and ATPase activities. Membranes exposed to peroxynitrite showed aggregation and nitration of proteins and changes in protein organization detectable with a maleimide spin label.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Membrana Eritrocítica
/
Eritrócitos
/
Nitratos
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Polônia