Topically applied human recombinant monoclonal IgG1 antibody and its Fab and F(ab')2 fragments protect mice from vaginal transmission of HSV-2.
Virology
; 225(1): 213-5, 1996 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-8918548
ABSTRACT
A recombinant human anti-herpes simplex virus monoclonal IgG1, antibody and the corresponding Fab and F(ab')2 fragments were tested for efficacy in preventing vaginal transmission of HSV-2 infection in a well-established mouse model for genital herpes. IgG1, Fab, and F(ab')2 were approximately equally protective; vaginal delivery of 1-5 ng provided approximately 50% protection, and vaginal delivery of 400 ng completely protected mice from genital herpes infection (P < 0.001). These results suggest that topical applications of human monoclonal antibodies may be useful in developing new methods for preventing sexually transmitted disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos Fab das Imunoglobulinas
/
Herpes Genital
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Herpesvirus Humano 2
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Anticorpos Monoclonais
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Anticorpos Antivirais
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Virology
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos