Gas chromatographic quantitation of dextropropoxyphene and norpropoxyphene in urine after solid-phase extraction.
J Anal Toxicol
; 20(7): 547-54, 1996.
Article
em En
| MEDLINE
| ID: mdl-8934304
ABSTRACT
A gas chromatographic technique with flame ionization detection, which is based on a solid-phase extraction (SPE) procedure using mixed-mode SPE columns, for the simultaneous quantitation of dextropropoxyphene and norpropoxyphene in urine is presented. Urine is treated with sodium hydroxide in order to rearrange, by base catalysis, norpropoxyphene to norpropoxyphene amide, which is then extracted with these columns and chromatographed. The method is specific, linear over the range 0-2000 ng/mL, sensitive, and reproducible. The extracts are cleaner than those obtained with traditional liquid-liquid extraction procedure, which is an important feature in view of further mass spectrometric confirmation of narcotics and other drugs.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dextropropoxifeno
/
Detecção do Abuso de Substâncias
/
Cromatografia Gasosa
/
Analgésicos Opioides
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Anal Toxicol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
França