Hypothyroidism alters the effect of GTP on adenylyl cyclase in forebrain and hindbrain synaptosomal membranes from 15-day-old rats.
Int J Dev Neurosci
; 14(6): 701-5, 1996 Oct.
Article
em En
| MEDLINE
| ID: mdl-8960977
ABSTRACT
The effect of GTP concentration of forskolin-stimulated adenylyl cyclase activity was examined in synaptosomal membranes from 15-day-old rats that were hypothyroid owing to administration of propylthiouracil and a low-iodine diet to the mothers during pregnancy and suckling. In membranes from the forebrain hypothyroidism abolished the overall stimulatory effect of GTP, which was seen in the euthyroid case. In membranes from the hindbrain hypothyroidism had the opposite effect in that there was an enhancement of an overall stimulatory effect of GTP. It is suggested that these findings reflect changes during early development of the brain in the expression of various G-proteins and/or the expression of different isoforms of adenylyl cyclase.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinaptossomos
/
Rombencéfalo
/
Adenilil Ciclases
/
Prosencéfalo
/
Hipotireoidismo
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Int J Dev Neurosci
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Reino Unido