Hormonal regulation of cardiac cystic fibrosis transmembrane conductance regulator chloride channels.
Jpn Heart J
; 37(5): 661-71, 1996 Sep.
Article
em En
| MEDLINE
| ID: mdl-8973379
ABSTRACT
The chloride conductance that arises from the stimulation of beta-adrenoceptors has been shown to be carried by a cardiac isoform of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels. This brief review will focus first upon the cellular signal transduction system for the activation of this type of Cl- channels and then its regulation by catecholamines, muscarinic agonists, endothelin-1 and angiotensin-II. Both in physiological and pathological conditions, the complex interaction of these agonists modulates the Cl- conductance, which is potentially arrhythmogenic by shortening the action potential duration and inducing the depolarization.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Angiotensina II
/
Catecolaminas
/
Canais de Cloreto
/
Regulador de Condutância Transmembrana em Fibrose Cística
/
Endotelina-1
/
Miocárdio
Limite:
Animals
Idioma:
En
Revista:
Jpn Heart J
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Japão