Progesterone-independent activation of rat brain progestin receptors by reproductive stimuli.
Endocrinology
; 138(1): 511-4, 1997 Jan.
Article
em En
| MEDLINE
| ID: mdl-8977442
ABSTRACT
Activation of steroid hormone receptors by steroid hormones alters both the physiology and behavior of animals. Steroid hormone receptors (e.g., progestin receptors) can also be activated in the absence of steroid hormones by pharmacological treatment with neurotransmitters or neuropeptides. However, it is not known if progesterone-independent activation of brain progestin receptors occurs under natural, physiological, conditions. We report that increases in reproductive behavior and brain immediate early gene expression in female rats induced by mating stimuli can be blocked by prior treatment with progesterone antagonists in the absence of circulating progesterone. This suggests that progestin receptors are activated in a progesterone-independent manner by a physiologically relevant stimulus in female rats, thus implicating a novel pathway by which mating stimuli and other environmental influences could activate steroid receptors to influence neuronal response and behavior.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Progesterona
/
Comportamento Sexual Animal
/
Receptores de Progesterona
Limite:
Animals
Idioma:
En
Revista:
Endocrinology
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos