Virulence in mice of Orientia tsutsugamushi isolated from patients in a new endemic area in Japan.
Microbiol Immunol
; 40(10): 743-7, 1996.
Article
em En
| MEDLINE
| ID: mdl-8981347
ABSTRACT
Four strains of Orientia tsutsugamushi (KN-1, KN-2, KN-3 and GJ-1) isolated from patients in an area of Gifu Prefecture, Japan, in which tsutsugamushi disease is newly endemic, were examined for their virulence in mice. Among these, KN-1 (identified as Kawasaki type), GJ-1 (identified as Kuroki type) and KN-2 strains were found to be non-lethal for BALB/c mice as well as CH3/HeJ mice, even with high doses (10(6) x being the 50% mouse infectious dose). On the other hand, the KN-3 strain was found to be sufficiently virulent to kill BALB/c mice. Among the prototype strains (Gilliam, Karp and Kato), the Karp and Kato strains exhibited high virulence to mice, while the Gilliam strain killed only a susceptible strain of mouse. BALB/c mice infected with KN-1 and KN-2 strains showed significant splenomegaly and moderate ascites accumulation in the first week of infection, while these symptoms became prominent during the second week of infection using KN-3, Karp and Kato strains. After infection with the GJ-1 strain, these symptoms were not observed. Antibody responses induced by infections with highly virulent strains were lower than that with low or intermediate virulent strains.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Orientia tsutsugamushi
/
Rickettsiaceae
/
Tifo por Ácaros
/
Doenças Endêmicas
Limite:
Animals
País/Região como assunto:
Asia
Idioma:
En
Revista:
Microbiol Immunol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Japão