Effect of 2-methyltaurine and its enantiomers on arterial blood pressure.
Pharmacol Res
; 34(1-2): 33-6, 1996.
Article
em En
| MEDLINE
| ID: mdl-8981553
ABSTRACT
Taurine has been shown to exert many biological effects. Among them, the ability of this amino acid to induce a reduction of arterial blood pressure, when administered intracerebroventricularly (i.c.v.) to mammals, has been established since a long time ago. To gain further information on the structure-activity requirements for taurine's hypotensive effect, the synthesis of 2-methyltaurine (2-aminopropanesulphonic acid) and the asymmetric synthesis of its enantiomers were performed; the enantiomeric purity of (R)- and (S)-2-methyltaurine was assayed by differential scanning calorimetry (DSC) and HPLC. The findings here reported show that the hypotensive effect elicited by the i.c.v. administration of racemate is mainly due to the (S)-enantiomer. The specificity of this effect was proved by the ability of the taurine antagonist TAG (6-aminomethyl-4H-3-methyl-1,2,4-benzothiadiazine 1,1-dioxide) to prevent it.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Taurina
/
Pressão Sanguínea
/
Anti-Hipertensivos
Limite:
Animals
Idioma:
En
Revista:
Pharmacol Res
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Itália