Distribution of fasting serum insulin measured by enzyme immunoassay in an unselected population of 4,032 individuals. Reference values according to age and sex. D.E.S.I.R. Study Group. Données Epidémiologiques sur le Syndrome d'Insulino-Résistance.
Diabetes Metab
; 22(6): 427-31, 1996 Dec.
Article
em En
| MEDLINE
| ID: mdl-8985651
ABSTRACT
As hyperinsulinaemia has been shown to be a risk factor for non-insulin-dependent diabetes, cardiovascular disease and hypertension, the measurement of serum insulin levels may provide an additional early screening test for these diseases. Biological assaying of insulin is now facilitated by the IMx-Abbott kit, an enzyme immunoassay which does not cross-react with proinsulin and thus provides more specific insulin determination than conventional methods. Fasting insulin concentrations were determined in a population of 4,032 men and women 30 to 64 years of age, all volunteers for a medical check-up. Concentrations were slightly higher for men in all age-classes (median values of 5.9 and 5.4 microU/ml respectively for men and women). Although significant differences were found in serum insulin concentrations between the four age-classes for men and women, there were no significant differences between the three age-classes for men up to 59 years (median 5.8 microU/ml, 95th percentile 14.0 microU/ml) or between the two age-classes for women up to 49 years (5.2, 12.5). Fasting concentrations were increased above these age thresholds men (6.4, 15.6), women (5.6, 14.0). The reference population consisted of 3,081 non-diabetic, glycosuria-negative subjects with a body mass index and glucose concentration lower than the 95th percentiles for their age and sex. The reference values for fasting insulin concentrations were 1) women 30-49 years median 5.1 microU/ml (95% confidence interval 4.9-5.3), 95th percentile 11.2 microU/ml (10.9-11.9); and 2) men 30-64 years and women 50-64 years median 5.6 microU/ml (5.4-5.7), 95th percentile 12.6 microU/ml (12.0-13.0).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hiperinsulinismo
/
Insulina
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Diabetes Metab
Assunto da revista:
ENDOCRINOLOGIA
/
METABOLISMO
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
França