Role of radiotherapy in the treatment of small cell lung carcinoma.

Radiotherapy is an important component in the treatment of limited stage small cell carcinoma of the lung. It improves both local control and survival. This article reviews the scientific and clinical data that have led to combined therapy being considered the current standard for care of limited stage disease. Questions of radiation dose, treatment volume, fractionation, and integration with chemotherapy are discussed. New avenues of investigation to reduce toxicity and optimize treatment efficacy are also discussed.