The burst phenomenon, an animal model simulating the long-term tissue response on PLLA interlocking nails.
J Biomed Mater Res
; 30(2): 139-43, 1996 Feb.
Article
em En
| MEDLINE
| ID: mdl-9019477
ABSTRACT
In this in vivo study, low-molecular-weight as-polymerized PLLA powder was placed in the medullary cavity of a porcine femur in order to study the tissue reaction on predegradated PLLA. An attempt was made to simulate the long-term degradation of a large PLLA implant. This phase can be characterized by the release of PLLA particles and acid compounds from a heterogeneously degrading PLLA implant into the surrounding tissues. The clinical consequences and tissue response were studied. The clinical recovery of the experimental animals was favorable. No signs of clinical inflammation could be detected during the eight-week follow-up period. Histological analysis of the bone/PLLA interface showed signs of a mild inflammatory tissue response.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Osso e Ossos
/
Pinos Ortopédicos
/
Ácido Láctico
Limite:
Animals
Idioma:
En
Revista:
J Biomed Mater Res
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Holanda