Synthesis and cholinesterase inhibitory activity of 6-, 7-methoxy-(and hydroxy-) tacrine derivatives.
Farmaco
; 51(11): 693-8, 1996 Nov.
Article
em En
| MEDLINE
| ID: mdl-9035375
ABSTRACT
Some 6- and 7-methoxy-(and hydroxy-) tacrine derivatives were synthesized and evaluated for their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities. The most potent analogue in our series was the 9-heptylamino-6-methoxytacrine 3af which, in comparison with tacrine (THA), displayed an almost identical inhibitory effect, slightly lower acute toxicity and higher selectivity profile towards AchE when compared with THA.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tacrina
/
Inibidores da Colinesterase
Limite:
Animals
Idioma:
En
Revista:
Farmaco
Assunto da revista:
FARMACOLOGIA
/
QUIMICA
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Itália