A critical review of genetic studies of schizophrenia. II. Molecular genetic studies.
Acta Psychiatr Scand
; 95(2): 73-80, 1997 Feb.
Article
em En
| MEDLINE
| ID: mdl-9065669
ABSTRACT
Recent molecular genetic studies of schizophrenia have, until now, been unable to demonstrate any specific major gene for schizophrenia. On the contrary, linkage and association studies have yielded almost exclusively negative or contradictory results. Such studies have involved certain candidate genes, such as the genes for dopamine receptors and other brain neurotransmitters. Some of these candidate genes have now actually been excluded as specific aetiological factors in schizophrenia. Similarly, studies searching for a major gene for susceptibility to schizophrenia involving the whole human genome or large parts of chromosomes have not yielded unambiguously positive results. However, the most recent empirical evidence suggests that many polygenes, acting together, could constitute a risk factor for schizophrenia. It is thus most probable that genetic susceptibility to schizophrenic psychoses is polygenic, and that their effects are dependent on interaction with physical and psychosocial environmental factors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Psicologia do Esquizofrênico
/
Biologia Molecular
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Acta Psychiatr Scand
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Finlândia