Dietary intake of myo-inositol and neural tube defects in offspring of diabetic rats.
Am J Obstet Gynecol
; 176(3): 536-9, 1997 Mar.
Article
em En
| MEDLINE
| ID: mdl-9077602
ABSTRACT
OBJECTIVE:
Embryopathy in diabetic mothers occurs at a rate four to five times higher than that observed in the general population. The current investigation was undertaken to assess the use of dietary myo-inositol supplementation as a pharmacologic prophylaxis to obviate the teratogenic effects of hyperglycemia in an in vivo study. STUDYDESIGN:
Seventy Sprague-Dawley rats were mated and after conception were randomly divided into five groups one group was nondiabetic normal controls and four groups had diabetes experimentally induced with streptozotocin. Of the diabetic groups, one received the usual diet, whereas the others received, respectively, 0.08, 0.16, and 0.5 mg/day supplemental myo-inositol orally.RESULTS:
With the myo-inositol supplementation (0.08 mg/day), the incidence of neural tube defects was significantly reduced from 20.4% to 9.5% (p < 0.01). The most effective dosage of myo-inositol was 0.08 mg/day. Increasing the dose of myo-inositol beyond that level did not significantly reduce the rate of neural tube defects. However, the resorption rate was increased to 29.8%.CONCLUSION:
These data demonstrate that myo-inositol supplementation reduces the incidence of diabetic embryopathy and may serve as a pharmacologic prophylaxis against diabetes-induced congenital malformations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gravidez em Diabéticas
/
Diabetes Mellitus Experimental
/
Desenvolvimento Embrionário e Fetal
/
Inositol
/
Defeitos do Tubo Neural
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Am J Obstet Gynecol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos