Cerebellar spongiform degeneration induced by acute lithium intoxication in the rat.
Neurosci Lett
; 224(1): 25-8, 1997 Mar 07.
Article
em En
| MEDLINE
| ID: mdl-9132682
ABSTRACT
Cerebellar syndrome has been described after acute lithium intoxication in human. Neuropathological studies have demonstrated neuronal loss and spongiosis in the cerebellum. We describe an animal model of acute lithium-induced cerebellar degeneration. Five hours following administration of lithium chloride (250 mg/kg, i.p.), the cerebellar white matter of seven rats out 14 exhibited extensive spongiform changes. Microdialysis study in the rat cerebellar cortex demonstrated basal concentrations of dopamine (DA), hydroxy-3-methoxyphenylacetic acid (HVA) and 5-hydroxy-3-indolacetic acid (5-HIAA). These metabolites were unaffected by acute lithium intoxication suggesting that the cerebellar toxicity is not due to a modification of dopaminergic or serotoninergic neurotransmission.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cerebelares
/
Lítio
/
Degeneração Neural
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Bélgica