First-pass metabolism and biliary recirculation of droloxifene in the female Sprague-Dawley rat.
Xenobiotica
; 27(3): 257-64, 1997 Mar.
Article
em En
| MEDLINE
| ID: mdl-9141233
ABSTRACT
1. Utilizing a validated ultrasensitive hplc assay (lower limit of quantitation 25 pg/ml), we characterized the disposition profile of droloxifene in the female Sprague-Dawley rat following intravenous, oral and intraportal administration. 2. The site and extent of first-pass metabolism and the extent of enterohepatic recirculation were investigated. 3. Our findings suggest that the intestine is neither a metabolic nor an absorptive barrier to the bioavailability of droloxifene in the female Sprague-Dawley rat and that first-pass hepatic extraction is approximately 70-80% following an oral dose of 1 mg/kg. 4. Employment of a modified linked-rat model revealed that droloxifene is subject to enterohepatic recirculation (approximately 5%) in the rat.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tamoxifeno
/
Bile
/
Antagonistas de Estrogênios
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Xenobiotica
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos