Release of histamine from dural mast cells by substance P and calcitonin gene-related peptide.
Cephalalgia
; 17(3): 166-74, 1997 May.
Article
em En
| MEDLINE
| ID: mdl-9170339
ABSTRACT
The aim of the present study was to examine if the neuropeptides substance P (SP), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) can stimulate histamine release from mast cells in the dura mater and thereby play a role in cranial vasoregulation and local neurogenic inflammation. Dura mater mast cells were compared with peritoneal mast cells in the rat. Histamine was released from dura mater mast cells by compound 48/80, SP and CGRP but from peritoneal mast cells only by compound 48/80 and SP. NPY and VIP released quite small amounts of histamine from dural mast cells. The release of SP and CGRP from rat dura mater mast cells was blocked by the receptor antagonists FK888 and CGRP8-37 respectively, suggesting receptor mediated release mechanisms. None of the stimuli released histamine from human or porcine dural mast cells, possibly because the sampling procedure injures and incapacitates the cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Histamina
/
Substância P
/
Peptídeo Relacionado com Gene de Calcitonina
/
Dura-Máter
/
Mastócitos
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Cephalalgia
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Suécia