Penicillin-binding protein 5 as an inhibitory target of cefozopran in Enterococcus faecalis.
J Antimicrob Chemother
; 37(3): 605-9, 1996 Mar.
Article
em En
| MEDLINE
| ID: mdl-9182117
ABSTRACT
The concentration of cefozopran which inhibits binding of [14C]benzylpenicillin to penicillin-binding protein (PBP) 5 of Enterococcus faecalis TN2OO5 by 50% was 11 mg/L, and its MIC was 12.5 mg/L. Ceftazidime and cefmenoxime, which were inactive at 100 mg/L, showed no affinity for PBP 5 at this concentration. Ampicillin, benzylpenicillin and imipenem showed higher affinity for PBPs 3/4 and PBP 5 than cefozopran, and their MICs were lower than that of cefozopran. No correlation between MICs of the test compounds and the affinity for PBP 1, 2 or 6 was found. These results suggest that cefozopran exhibits antimicrobial activity against E. faecalis TN2OO5 by binding to PBP 5.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Muramilpentapeptídeo Carboxipeptidase
/
Proteínas de Transporte
/
Cefalosporinas
/
Peptidil Transferases
/
Enterococcus faecalis
/
Hexosiltransferases
Idioma:
En
Revista:
J Antimicrob Chemother
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Japão
País de publicação:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM