Hypertonic saline administration attenuates spinal cord injury.
J Trauma
; 42(5 Suppl): S54-60, 1997 May.
Article
em En
| MEDLINE
| ID: mdl-9191697
ABSTRACT
BACKGROUND:
This manuscript describes the results of three studies designed to test the hypothesis that the intravenous administration of hypertonic saline could help to preserve spinal cord function after injury.METHODS:
A static compression model was used to injure rat spinal cords. Somatosensory evoked potentials and spinal cord blood flow changes were monitored in the acute studies. The first study compared the effects of administration of hypertonic saline with isotonic saline solutions. The second study evaluated the effect of hypertonic saline administration at 5, 15, and 60 minutes after injury. A chronic injury model was evaluated in the third study. Spontaneous voiding, neurologic function, and evidence of histologic changes were evaluated. RESULTS ANDCONCLUSIONS:
The administration of hypertonic saline after spinal cord injury increased blood flow and helped preserve spinal cord function in the acute models. The rate of recovery with the chronic model was significantly faster in hypertonic saline treated animals.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Solução Salina Hipertônica
/
Traumatismos da Medula Espinal
Tipo de estudo:
Clinical_trials
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
J Trauma
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos