Tissue factor in health and disease.
Thromb Haemost
; 78(1): 759-64, 1997 Jul.
Article
em En
| MEDLINE
| ID: mdl-9198252
ABSTRACT
Over the last years numerous studies have focussed on the in vivo expression of tissue factor (TF) in health and disease. The selective perivascular distribution of TF and the lethal effects of TF knockouts have added strong support to the widely accepted view that TF plays a pivotal role in the initiation of blood coagulation during physiological hemostasis. Inappropriate in vivo expression of TF, particularly by cells that do not express this protein under normal conditions (mainly monocyte-macrophages and endothelial cells), has been documented and is likely responsible for fibrin deposition in a variety of pathological conditions, among which sepsis-associated disseminated intravascular coagulation (DIC) and thromboembolic disease. In malignancy, in vivo expression of TF by tumor cells and/or by host cells has been implicated not only in intratumoral and systemic activation of blood coagulation but also in tumor growth and dissemination.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arteriosclerose
/
Trombose
/
Tromboplastina
/
Coagulação Intravascular Disseminada
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Thromb Haemost
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Itália