Tumor cell growth is inhibited by suppressing metallothionein-I synthesis.
Cancer Lett
; 116(2): 145-9, 1997 Jun 24.
Article
em En
| MEDLINE
| ID: mdl-9215857
ABSTRACT
The effect of metallothionein (MT)-I antisense oligodeoxynucleotide (ODN) on the growth of three kinds of tumor cells was studied, since MTs may be involved in cell growth. When MT-I antisense ODN was added to leukemia P388 cells, cell growth was inhibited in a manner dependent on the dose and incubation time. MT-I antisense ODN was also inhibitory for other tumor cell lines, i.e. Ehrlich carcinoma and sarcoma 180. A significant decrease in the level of MT, but not of Zn, was observed in MT-I antisense ODN-treated cells. On the other hand, control ODN did not inhibit the cell growth appreciably. These results indicate that MT-I expression may be necessary for the growth and survival of these tumor cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos Antissenso
/
Metalotioneína
/
Neoplasias Experimentais
Limite:
Animals
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Japão