Metabolic defects caused by treatment with the tetrahydropyridine analog of haloperidol (HPTP), in baboons.
Life Sci
; 61(3): 265-72, 1997.
Article
em En
| MEDLINE
| ID: mdl-9217286
ABSTRACT
Mounting evidence suggests that compromised cellular energy production is a major contributor to idiopathic and drug-induced degenerative processes. Our interest in neurotoxins have prompted us to examine in the baboon the effects of HPTP, the tetrahydropyridine dehydration product of haloperidol, on urinary chemical markers that reflect defects in mitochondrial respiration. Urinary dicarboxylic acid and conjugate profiles, similar to those seen in humans with inborn errors of mitochondrial metabolism and toxin-induced Jamaican vomiting sickness (JVS) were observed in the treated baboons. We interpret these results as evidence that HPTP and/or HPTP metabolites inhibit mitochondrial respiration in the baboon and speculate that analogous effects may occur in haloperidol-treated individuals.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Consumo de Oxigênio
/
Ácidos Dicarboxílicos
/
Oxirredutases atuantes sobre Doadores de Grupo CH-NH
/
Haloperidol
/
Proteínas Ferro-Enxofre
/
Mitocôndrias
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
África do Sul