Synthesis and properties of the first all-aza analogue of a biologically active peptide.
J Pept Sci
; 1(3): 201-6, 1995.
Article
em En
| MEDLINE
| ID: mdl-9222997
ABSTRACT
The synthesis of the first all-aza-amino acid analogue (2) of a peptidic renin inhibitor is described. The X-ray structural analysis and molecular modelling investigations of this novel compound reveal interesting conformational features which have a significant impact on its biological activity. In addition, insight into conformational features of azapeptides in general in comparison with the corresponding purely peptidic compounds is given.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Compostos Aza
Limite:
Humans
Idioma:
En
Revista:
J Pept Sci
Assunto da revista:
BIOQUIMICA
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Alemanha