Immune suppression and Th1/Th2 balance in pregnancy revisited: a (very) personal tribute to Tom Wegmann.
Am J Reprod Immunol
; 37(6): 427-34, 1997 Jun.
Article
em En
| MEDLINE
| ID: mdl-9228297
ABSTRACT
PROBLEM:
The paradigm of local suppression necessary to understand the survival of the fetal allograft is often compared with the host-tumor relationship.METHODS:
We investigated two components of local immune suppression placenta-induced immunosuppression, which is mediated at least in part by a soluble factor of low molecular weight that can induce anergy in lymphocytes, and interleukin-10 (IL-10).RESULTS:
We show that enhancement of IL-10 production in the decidua and placenta after alloimmunization requires the presence of Asialo GM1+ cells. Placenta-induced immunosuppression is linked with defects in phosphorylation of some components of the T cell receptor.CONCLUSION:
NK cells could be in fact regulatory cells pushing maternal immune response toward a Th2 profile, beneficial for fetal survival, or toward a Th1 type of immune response, which acts in synergy. Modulation of TcR may represent a new mechanism for maternal-fetal tolerance.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gravidez
/
Células Matadoras Naturais
/
Interleucina-10
/
Células Th2
/
Células Th1
/
Tolerância Imunológica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Am J Reprod Immunol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
França