[Erythropoietin gene: regulation and therapeutic concern]. / Gène de l'érythropoïétine: régulation et intérêt thérapeutique.
Hematol Cell Ther
; 39(2): 109-13, 1997 Apr.
Article
em Fr
| MEDLINE
| ID: mdl-9229543
ABSTRACT
The erythropoietin (Epo) is a model of proteins expressed upon hypoxia, regulated at the transcriptional and post transcriptional levels. The Hypoxia Induced Factor (HIF-I) activates the transcription of genes which exhibit the Hypoxia Regulatory Element (HRE). In addition the mRNA is stabilized upon hypoxia, increasing the hormone synthesis. The Epo gene is a convenient reporter gene to develop gene delivery systems and the in vivo regulation of the transgene. The beta thalassemia and acquired chronic anemias may benefit from the Epo gene transfer and expression, if it becomes safe, tunable and inexpensive.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação da Expressão Gênica
/
Eritropoetina
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
Fr
Revista:
Hematol Cell Ther
Assunto da revista:
HEMATOLOGIA
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
França