Automated chemical synthesis: from resins to instruments.
Mol Divers
; 2(4): 197-206, 1997.
Article
em En
| MEDLINE
| ID: mdl-9249755
ABSTRACT
Solid-phase organic synthesis is now a prevalent activity in drug discovery. In keeping with this keen interest is the need to develop reliable automated synthesis instrumentation as well as polymeric supports and linkers suitable for the full range of organic synthesis applications. In this paper, we review our activities in the development of new and enabling tools for automated chemical synthesis, including the following (i) new solid supports such as ArgoGel (PS-PEG-based) and Argo-X203 (PS-based); and (ii) the Nautilus 2400 system, a fully closed and inert automated chemistry development workstation. Selected chemistry optimization and synthesis examples performed on the Nautilus and new solid supports will be described.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resinas Vegetais
/
Bioquímica
Idioma:
En
Revista:
Mol Divers
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos