Direct spectrophotometric determination of sulfathiazole in presence of sulfadiazine and sulfamerazine.
J Pharm Sci
; 66(10): 1413-5, 1977 Oct.
Article
em En
| MEDLINE
| ID: mdl-925897
ABSTRACT
A direct spectrophotometric method for the quantitative determination of sulfathiazole and the total pyrimidyl sulfonamide content in a mixture containing sulfadiazine and sulfamerazine is reported. This three-component system was readily reduced to the problem of a simple two-component system analysis. Based on dual isoabsorptive wavelength spectroscopy, simultaneous equations were developed that required absorbance measurements at only two selected wavelengths both isoabsorptive. The location of the isoabsorptive wavelengths was dependent on the pH of the solvent medium, and 0.1 M HCl gave the best results. The validity of the derived equations was demonstrated in a recovery study involving synthetic mixtures containing varying quantities of the three sulfonamides. The recovery was linear over a wide concentration range, and the precision of the method was about 1%.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfadiazina
/
Sulfamerazina
/
Sulfatiazóis
Idioma:
En
Revista:
J Pharm Sci
Ano de publicação:
1977
Tipo de documento:
Article