Molecular analysis of a mobilizable theta-mode trimethoprim resistance plasmid from coagulase-negative staphylococci.
Plasmid
; 38(1): 13-24, 1997.
Article
em En
| MEDLINE
| ID: mdl-9281492
ABSTRACT
The Staphylococcus epidermidis plasmid pSK639 is the prototype of a newly described family of small plasmids identified in clinical staphylococcal isolates. pSK639 is 8 kb in length and possesses a composite structure consisting of an IS257-flanked segment mediating trimethoprim resistance (Tpr), and regions responsible for replication and mobilization of the plasmid. Comparative sequence analysis suggests that a pSK639-like plasmid may represent a progenitor of previously identified staphylococcal Tpr determinants related to the transposon-like structure, Tn4003. In contrast to the small staphylococcal plasmids characterized to date that all utilize a rolling circle mode of replication, the replication region of pSK639 was found to contain features typical of an iteron-controlled theta-mode replicon. pSK639 is the first small plasmid of this type to be identified in the staphylococci.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Staphylococcus epidermidis
/
Fatores R
/
Resistência a Trimetoprima
/
Genes Bacterianos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Plasmid
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Austrália