Effect of independent changes in mixed-venous PCO2 or PO2 on cardiac output in anesthetized sheep.
J Surg Res
; 71(2): 107-16, 1997 Aug.
Article
em En
| MEDLINE
| ID: mdl-9299277
ABSTRACT
To determine whether changes mixed-venous PCO2 or PO2 affect cardiac output independent of changes in arterial blood gases, we used extracorporeal gas exchange to increase mixed-venous PCO2 or decrease mixed-venous PO2 in adult sheep. Sheep were anesthetized, mechanically ventilated, and connected to a veno-venous extracorporeal circuit. The circuit included a gas exchanger which was used to increase mixed-venous PCO2 or decrease mixed-venous PO2; the native lungs were ventilated to maintain arterial PCO2 and PO2 at control levels. When mixed-venous PCO2 was increased by 32% above control levels for a period of 60 min, cardiac output increased significantly to 28% above control levels. Cervical vagotomy abolished this response. In contrast, decreasing mixed-venous PO2 by 29% did not increase cardiac output. These results demonstrate that increasing mixed-venous PCO2 can increase cardiac output independent of changes in arterial blood gases and that intact vagus nerves are necessary for this response to occur.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Dióxido de Carbono
/
Débito Cardíaco
Limite:
Animals
Idioma:
En
Revista:
J Surg Res
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos