Fos in locus coeruleus neurons following audiogenic seizure in the genetically epilepsy-prone rat: comparison to electroshock and pentylenetetrazol seizure models.
Neurosci Lett
; 233(1): 21-4, 1997 Sep 12.
Article
em En
| MEDLINE
| ID: mdl-9324230
ABSTRACT
Seizures in genetically epilepsy-prone rats (GEPRs) may result from hypoactivity of locus coeruleus (LC) neurons during seizures. This study examined Fos-like-immunoreactivity (FLI) in the LC following audiogenic seizures in two strains of GEPRs (GEPR-9s and -3s), and following pentylenetetrazol (PTZ) or maximal electroshock seizures (MES) in normal rats. After tonic seizure, GEPR-9s showed an identical LC-FLI response to that of normal rats following tonic seizures induced by either PTZ or MES. GEPR-3s, having clonic seizures, had less FLI in the LC. Therefore, stimulus-transcription coupling in the GEPR LC is apparently normo-typic in its FLI response to seizure and thus is not likely the root cause of NE abnormalities in this seizure model.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Locus Cerúleo
/
Proteínas Proto-Oncogênicas c-fos
/
Modelos Animais de Doenças
/
Epilepsia
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos