Comparative study of CD26 as a Th1-like and CD30 as a potential Th2-like operational marker in leprosy.
Adv Exp Med Biol
; 421: 217-21, 1997.
Article
em En
| MEDLINE
| ID: mdl-9330700
ABSTRACT
In the last years we have been able to establish CD26 as an operational marker for a human Th1-like reaction in various granulomatous diseases. Recently, CD30 was described as a marker for a Th2-type reaction, where CD30 is preferentially expressed and its soluble form released by human T cell clones producing Th2-type cytokines. To evaluate the possibility of CD30 as an eventual operational marker for a human Th2-like reaction in vivo, we performed immunohistological stainings on frozen sections of skin biopsies from patients with lepromatous and tuberculoid leprosy. A maximum of three to four CD30-positive cells was found per section, and there was no difference in the accumulation of CD30-positive cells between the tuberculoid and the lepromatous form of leprosy. With respect to CD26-positive cells, a high number was found in tuberculoid leprosy in contrast to a greatly reduced expression of CD26 in lepromatous leprosy. We conclude that, while CD26 was confirmed as an operational marker for a Th1-like reaction in leprosy, CD30 does not represent an operational Th2 marker in this disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígeno Ki-1
/
Células Th2
/
Células Th1
/
Dipeptidil Peptidase 4
/
Hanseníase
Limite:
Humans
Idioma:
En
Revista:
Adv Exp Med Biol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Alemanha