Ganglionitis in paraneoplastic subacute sensory neuronopathy: a morphologic study.
Neurology
; 49(4): 1156-9, 1997 Oct.
Article
em En
| MEDLINE
| ID: mdl-9339709
ABSTRACT
A 69-year-old woman presented with subacute sensory neuropathy and autonomic dysfunction of 9 months' duration, associated with high serum titers of anti-Hu antibodies. A small cell carcinoma of the lung was diagnosed by biopsy. She died after cardiorespiratory arrest. At autopsy, spinal and autonomic ganglia showed subacute inflammation with diffuse endoneurial T-cell, B-cell, and plasma cell infiltration. The cytoplasm and nuclei of some ganglion neurons displayed IgG immunocytochemical positivity. CD8+ T cells were tightly attached to, and indented the cell surface of, IgG-positive and IgG-negative neurons. This observation suggests that both cytotoxic T-cell-mediated attack against neurons and humoral mechanisms play a role in paraneoplastic subacute sensory neuronopathy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndromes Paraneoplásicas
/
Transtornos de Sensação
/
Gânglios Autônomos
/
Gânglios Espinais
/
Neurite (Inflamação)
Limite:
Aged
/
Female
/
Humans
Idioma:
En
Revista:
Neurology
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Áustria