Interleukin-6-dependent and -independent regulation of the human C-reactive protein gene.
Biochem J
; 327 ( Pt 2): 425-9, 1997 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-9359411
ABSTRACT
We have investigated the function of different mediators of the regulation of the human C-reactive protein (hCRP) gene in transgenic mice. hCRP was induced by lipopolysaccharide and wounding in interleukin-6 (IL-6) +/+ mice, but not in IL-6 -/- mice. This finding suggested that IL-6 is necessary for the induction of hCRP. However, injection of IL-6 did not induce the hCRP gene. Thus, the induction of hCRP by IL-6 seems to require an additional cofactor. Therefore, we screened different cytokines for their activity in IL-6 +/+ and IL-6 -/- mice. Surprisingly, interleukin-1beta, as well as oncostatin M or leukaemia inhibitory factor, led to an induction of hCRP in both genetic backgrounds. These results indicate an IL-6-dependent and -independent regulation of hCRP. These hCRP transgenic mice therefore represent a novel model system for defining the cytokine network involved in the regulation of acute-phase genes during the course of inflammation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Proteína C-Reativa
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Regulação da Expressão Gênica
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Citocinas
/
Interleucina-6
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biochem J
Ano de publicação:
1997
Tipo de documento:
Article