Peripheral-type benzodiazepine receptors.
Gen Pharmacol
; 29(3): 305-14, 1997 Sep.
Article
em En
| MEDLINE
| ID: mdl-9378234
ABSTRACT
1. The pharmacological effects of benzodiazepines are mediated through a class of recognition sites associated with the gamma-aminobutyric acid A receptor. A second class of benzodiazepine binding sites is found in virtually all mammalian peripheral tissues and is therefore called the peripheral type benzodiazepine receptor (PBR). 2. The first section of this review describes the tissue and subcellular distribution of the PBR in mammalian tissues and analyzes its many putative endogenous ligands. 3. The next section deals with the pharmacological, structural and molecular characterization of the PBR that has taken place in the past few years. 4. The final section describes the possible physiological role(s) of the PBR and identifies future work that would help deepen our understanding of the PBR and its function.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Nervoso Periférico
/
Receptores de GABA-A
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Gen Pharmacol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Irlanda
País de publicação:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM