In search of optimal long-term female hormone replacement: the potential of selective estrogen receptor modulators.
Horm Res
; 48(4): 155-63, 1997.
Article
em En
| MEDLINE
| ID: mdl-9378461
ABSTRACT
Selective estrogen receptor modulators (SERMs) comprise a group of structurally diverse compounds which are distinguished from estrogens by their ability to interact with the estrogen receptor but to act as either an estrogen agonist or antagonist depending on the target tissue and hormonal milieu. The mechanisms by which SERMs elicit tissue-specific responses are being intensively investigated, and recently a novel pathway for estrogen receptor-mediated gene activation by the SERM raloxifene has been demonstrated. The tissue-specific activity of SERMs suggests that they may be clinically useful as, for example, potential substitutes for long-term female hormone replacement therapy. Large-scale clinical testing currently in progress for raloxifene, and soon to begin for other SERMs, will evaluate this important potential.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Estrogênio
/
Terapia de Reposição de Estrogênios
Limite:
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Horm Res
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos