Antitumor activity of conjugates of the oncofetal protein alpha-fetoprotein and phthalocyanines in vitro.
Biochem Mol Biol Int
; 43(4): 873-81, 1997 Nov.
Article
em En
| MEDLINE
| ID: mdl-9385447
ABSTRACT
The several conjugates of aluminium and cobalt complexes of phthalocyanines with human alpha-fetoprotein have been synthesized. Their cytotoxic activity against tumor cells and human peripheral blood lymphocytes was studied. The experimental data demonstrate that the cytotoxic activity of alpha-fetoprotein-phthalocyanine conjugates against three types of tumor cells of various origin is much higher (for aluminium and cobalt complexes more than 1000 and 50 times, respectively) in comparison with phthalocyanines themselves. The application of phthalocyanines as conjugates with alpha-fetoprotein makes it possible to markedly enhance the selective toxicity of phthalocyanines against human tumor cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Alfa-Fetoproteínas
/
Imunotoxinas
/
Indóis
/
Antineoplásicos
Limite:
Female
/
Humans
Idioma:
En
Revista:
Biochem Mol Biol Int
Assunto da revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Federação Russa