T and B cell development in pituitary deficient insulin-like growth factor-II transgenic dwarf mice.
J Endocrinol
; 155(1): 165-70, 1997 Oct.
Article
em En
| MEDLINE
| ID: mdl-9390019
Treatment of mice with IGF-I stimulates T and B cell development. We showed that overexpression of IGF-II in transgenic FVB/N mice only stimulated T cell development. In the present study, we further addressed the in vivo effects of IGF-II in the absence of IGF-I to get more insight into the potential abilities of IGF-II to influence T and B cell development. To this end, we studied lymphocyte development in IGF-II transgenic Snell dwarf mice that are prolactin, GH and thyroid-stimulating hormone deficient and as a consequence show low serum IGF-I levels. We showed that T cell development was stimulated to the same extent as in IGF-II transgenic FVB/N mice. Furthermore, IGF-II increased the number of nucleated bone marrow cells and the number of immature B cells without having an effect on the number of mature B cells in spleen and bone marrow. Our data show that IGF-II has preferential effects on T cell development compared with B development, and that these preferential effects also occur in the absence of measurable IGF-I levels.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Insulin-Like I
/
Fator de Crescimento Insulin-Like II
/
Linfócitos B
/
Linfócitos T
/
Nanismo
Limite:
Animals
Idioma:
En
Revista:
J Endocrinol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Holanda
País de publicação:
Reino Unido