Suppression of A beta-induced monocyte neurotoxicity by antiinflammatory compounds.
J Neuroimmunol
; 80(1-2): 6-12, 1997 Dec.
Article
em En
| MEDLINE
| ID: mdl-9413254
ABSTRACT
Previous work from this laboratory has demonstrated that prior exposure of peripheral blood monocytes (PBM) to aggregated beta-amyloid peptide (A beta), the major protein comprising the amyloid plaques characteristically present in the brain of Alzheimer disease (AD)-afflicted individuals, activates these cells to a neurotoxic state when co-cultured with brain tissue. In this report we extend these findings to further show that such A beta-induced PBM neurotoxicity can be inhibited by three differentially-acting antiinflammatory drugs, indomethacin, dexamethasone, and colchicine, which are typically used clinically to treat peripheral inflammatory disease. In addition, evidence is presented that these toxic effects are initiated, in large part, by soluble factors released from A beta-stimulated PBM. Our results suggest a rationale for antiinflammatory therapy in the treatment of AD.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Monócitos
/
Peptídeos beta-Amiloides
/
Imunossupressores
/
Anti-Inflamatórios
/
Neurotoxinas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos