Inhibition of Fe(II) catalyzed linoleic acid oxidation and DNA damage by phosvitin.
Mol Cell Biochem
; 177(1-2): 47-51, 1997 Dec.
Article
em En
| MEDLINE
| ID: mdl-9450644
ABSTRACT
The oxidation of linoleic acid catalyzed by Fe(II) is strongly inhibited by phosvitin, while chelation with EDTA, NTA or deferoxamine produced only partial inhibition. Interestingly, the DNA degradation catalyzed by Fe(II) in the presence of H2O2 is also inhibited by phosvitin or deferoxamine. In contrast, chelation of the metal ion with EDTA or NTA enhanced the DNA degradation. The results suggest that the nature of interaction between the metal ion and the complexing agent may be an important factor in the generation of active oxygen intermediates.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Compostos Ferrosos
/
Fosvitina
/
Ácido Linoleico
Limite:
Animals
Idioma:
En
Revista:
Mol Cell Biochem
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Índia