Comparative mapping of human alphoid satellite DNA repeat sequences in the great apes.
Genetica
; 101(2): 97-104, 1997.
Article
em En
| MEDLINE
| ID: mdl-9465402
ABSTRACT
Heterochromatic regions of chromosomes contain highly repetitive, tandemly arranged DNA sequences that undergo very rapid variation compared to unique DNA sequences that are predominantly conserved. In this study the chromosomal basis of speciation has been looked at in terms of repeat sequences. We have hybridized twenty-one chromosome-specific human alphoid satellite DNA probes to metaphase spreads of the chimpanzee (Pan troglodytes), gorilla (Gorilla gorilla), and orangutan (Pongo pygmaeus) to investigate the evolutionary relationship of heterochromatic regions among such hominoid species. The majority of the probes did not hybridize to their corresponding equivalent chromosome but presented hybridization signals on non-corresponding chromosomes. Such observations suggest that rapid changes may have occurred in the ancestral alphoid satellite DNA sequence, resulting in divergence among the great ape species.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA Satélite
/
Sequências Repetitivas de Ácido Nucleico
/
Hominidae
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Genetica
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos