Evaluation of risperidone in the neonatal 6-hydroxydopamine model of Lesch-Nyhan syndrome.
Pharmacol Biochem Behav
; 59(2): 327-30, 1998 Feb.
Article
em En
| MEDLINE
| ID: mdl-9476977
ABSTRACT
Rats were treated as neonates with 6-hydroxydopamine (6-OHDA) 100 mg free base in 10 microl intracisternally. Upon maturation, animals were injected with L-dopa and placed in photocell cages for monitoring of locomotion, stereotypies, and self-mutilation. Pretreatment with either risperidone or SCH-23390 significantly reduced locomotion and stereotypies. SCH-23390 eliminated L-dopa induced self-mutilation in all subjects, while risperidone eliminated self-mutilation in all but one subject.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Simpatolíticos
/
Oxidopamina
/
Antagonistas de Dopamina
/
Risperidona
/
Síndrome de Lesch-Nyhan
Limite:
Animals
Idioma:
En
Revista:
Pharmacol Biochem Behav
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos