The gene defective in anhidrotic ectodermal dysplasia is expressed in the developing epithelium, neuroectoderm, thymus, and bone.
J Histochem Cytochem
; 46(3): 281-9, 1998 Mar.
Article
em En
| MEDLINE
| ID: mdl-9487109
ABSTRACT
Anhidrotic ectodermal dysplasia (EDA) is characterized by defects in the development of teeth, hair, and sweat glands. To study the expression of the human gene defective in EDA in human fetal development (Weeks 6-23 of gestational age) and in adult tissues, in situ hybridization and immunohistochemistry were used. First signs of expression were detected at Week 8 in epidermis and in neuroectodermal cells. Starting at Week 12, osteoblasts and thymus were positive for EDA mRNA. Hair follicles expressed EDA mRNA from 18 weeks. The presence of the EDA protein coincided with mRNA expression in the tissues examined. The expression pattern of the EDA gene is consistent with typical involvement of the skin in the syndrome. However, the expression is not limited to the ectodermal tissues and many sites of expression are not obviously reflected in the clinical features of the syndrome.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Timo
/
Osso e Ossos
/
Displasia Ectodérmica
/
Sistema Nervoso Central
Limite:
Adult
/
Humans
Idioma:
En
Revista:
J Histochem Cytochem
Assunto da revista:
HISTOCITOQUIMICA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Finlândia