Delayed gastric emptying by Helicobacter pylori lipopolysaccharide in conscious rats.
Dig Dis Sci
; 43(1): 90-4, 1998 Jan.
Article
em En
| MEDLINE
| ID: mdl-9508541
ABSTRACT
The present study was carried out to investigate the possibility that lipopolysaccharide deprived from Helicobacter pylori may alter gastric motility. To address the question, we examined the effect of H. pylori lipopolysaccharide on gastric emptying in conscious rats. Gastric emptying was evaluated by the phenol red method. Time-course and dose-related effects of intraperitoneal administration of H. pylori lipopolysaccharide were investigated. Intraperitoneal injection of H. pylori lipopolysaccharide significantly suppressed gastric emptying of a liquid meal in a dose-dependent manner. The inhibitory action of H. pylori lipopolysaccharide was observed 2, 4, 8, or 12 hr after the injection. These results suggest for the first time that H. pylori lipopolysaccharide may suppress gastric emptying in a long-lasting fashion. It is also suggested that H. pylori may influence gastric function through its cell wall structure named lipopolysaccharide.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lipopolissacarídeos
/
Helicobacter pylori
/
Esvaziamento Gástrico
Limite:
Animals
Idioma:
En
Revista:
Dig Dis Sci
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Japão