Nitric oxide affects LTP in area CA1 and CA3 of hippocampus in low-level lead-exposed rat.
Neurotoxicol Teratol
; 20(1): 69-73, 1998.
Article
em En
| MEDLINE
| ID: mdl-9511171
ABSTRACT
Neonatal Wistar rats were exposed to lead from parturition to weaning via the milk of dams drinking 0.2% lead acetate solution. The alterations in EPSPs in areas CA1 and CA3 of hippocampal slices of 60-day-old adult rats following developmental lead exposure were studied. The results demonstrate that lead exposure in neonatal rats causes a decrease in LTP in area CA1 and an increase in LTP in area CA3. The effects of exposure to NO-generating compound sodium nitroprusside (SNP) on LTP in areas CA1 and CA3 of control and lead-exposed rats were also tested. The data demonstrate that NO causes an increase in LTP in area CA1 and no different alterations in area CA3 of lead-exposed rats. The results also demonstrate that NO may be a messenger molecule in areas CA1 and CA3. It suggests that lead might selectively interfere with specific neurochemical pathways in the hippocampus.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Potenciação de Longa Duração
/
Hipocampo
/
Intoxicação por Chumbo
/
Óxido Nítrico
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Neurotoxicol Teratol
Assunto da revista:
NEUROLOGIA
/
TOXICOLOGIA
Ano de publicação:
1998
Tipo de documento:
Article