Purine metabolism of uric acid urolithiasis induced in newborn piglets.
J Vet Med Sci
; 60(2): 203-6, 1998 Feb.
Article
em En
| MEDLINE
| ID: mdl-9524944
ABSTRACT
To clarify the relationship between uric acid urolithiasis and purine catabolites in newborn piglets, the incidence of uric acid urolithiasis and the plasma concentrations of xanthine, hypoxanthine, uric acid and allantoin were examined in 32 piglets. The newborn piglets were divided into two groups normal (over 1.2 kg, n = 18, group N) and low body weight (below 0.9 kg, n = 14, group L). The animals in both groups were given water (non-nutrition, n = 11, treatment W), artificial milk (normal nutrition, n = 12, treatment M), or a combination of water and allopurinol (prophylactic treatment for the urolithiasis, n = 9, treatment A), during the first 60-hr of birth. At necropsy, the incidence of urolithiasis was higher in the piglets that received treatment W than those in the treatment M or A in both the N and L groups. In group L, the plasma xanthine, hypoxanthine and uric acid concentrations were markedly increased in the piglets that underwent treatment W compared with the treatment M. In both the N and L groups, the plasma allantoin concentration was higher in the treatment W piglets as compared with the treatment M piglets. These results suggested that the occurrence of uric acid urolithiasis in the newborn piglets is attributable to increased purine catabolites due to a starvational condition after birth.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Purinas
/
Suínos
/
Doenças dos Suínos
/
Ácido Úrico
/
Cálculos Urinários
Limite:
Animals
Idioma:
En
Revista:
J Vet Med Sci
Assunto da revista:
MEDICINA VETERINARIA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Japão
País de publicação:
JAPAN
/
JAPON
/
JAPÃO
/
JP