Treatment of accidental high dose intraventricular mezlocillin application by cerebrospinal fluid exchange.
J Neurol Neurosurg Psychiatry
; 64(3): 379-81, 1998 Mar.
Article
em En
| MEDLINE
| ID: mdl-9527154
ABSTRACT
An accidental high dose of intraventricular mezlocillin was given during antibiotic treatment for pneumonia in a patient admitted because of severe traumatic brain injury and occlusive hydrocephalus. Because of serial epileptic seizures not responsive to antiepileptic drug treatment, CSF exchange was performed. The CSF was drained through a ventricular catheter, while mock CSF was infused into the lumbar subarachnoid space. The patient soon recovered to her clinical status previous to intraventricular mezlocillin application. Side effects of CSF exchange were not seen. Under continued antiepileptic medication no more seizures occurred. It is concluded that high doses of intraventricular mezlocillin have proconvulsive effects. In this patient CSF exchange was a suitable means of preventing putatively permanent impairment of brain function caused by serial epileptic seizures due to intraventricular mezlocillin application.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Penicilinas
/
Pneumonia
/
Ventriculostomia
/
Drenagem
/
Epilepsia
/
Hidrocefalia
/
Erros de Medicação
/
Mezlocilina
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
J Neurol Neurosurg Psychiatry
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Alemanha