Beta-catenin: a key mediator of Wnt signaling.
Curr Opin Genet Dev
; 8(1): 95-102, 1998 Feb.
Article
em En
| MEDLINE
| ID: mdl-9529612
ABSTRACT
Beta-catenin is a pivotal player in the signaling pathway initiated by Wnt proteins, mediators of several developmental processes. beta-catenin activity is controlled by a large number of binding partners that affect the stability and the localization of beta-catenin and is thereby able to participate in such varying processes as gene expression and cell adhesion. Activating mutations in beta-catenin and in components regulating its stability can contribute to the formation of certain tumors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Transativadores
/
Proteínas Proto-Oncogênicas
/
Proteínas do Citoesqueleto
/
Proteínas de Drosophila
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Genet Dev
Assunto da revista:
GENETICA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos