Dimeric inhibin serum values as markers of ovarian activity in pill-free intervals.
Contraception
; 57(1): 45-8, 1998 Jan.
Article
em En
| MEDLINE
| ID: mdl-9554250
ABSTRACT
PIP: Serum values of dimeric inhibin A and B were measured to assess the restoration of pituitary and ovarian activity during the pill-free interval in women taking combined oral contraceptives. 175 healthy women 18-35 years of age from five areas in Belgium were enrolled and monitored during routine gynecologic examinations. During the 7 day pill-free interval, inhibin B levels rose significantly in parallel with rising levels of follicle-stimulating hormone, luteinizing hormone, and estradiol. Progesterone levels were completely suppressed. Inhibin A levels rose slightly but insignificantly, reflecting an absence of development of preovulatory follicles. These findings indicate that inhibins are sensitive biochemical markers of ovarian activity in pill-free intervals. Inhibin B appears to be predominantly a product of the cohort of developing primary and subsequent early antral follicles, while inhibin A secretion is more indicative of dominant follicular and corpus luteum function.
Palavras-chave
Belgium; Biology; Clinical Research; Contraception; Contraceptive Methods--pharmacodynamics; Developed Countries; Endocrine System; Europe; Family Planning; Genitalia; Genitalia, Female; Hormones; Oral Contraceptives, Combined--pharmacodynamics; Oral Contraceptives--pharmacodynamics; Ovarian Effects; Ovary; Physiology; Pituitary Hormones; Research Methodology; Research Report; Urogenital System; Western Europe
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Progestinas
/
Congêneres do Estradiol
/
Etinilestradiol
/
Folículo Ovariano
/
Inibinas
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Contraception
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Bélgica