A CD4+ proliferation of large granular lymphocytes expresses the protease activated receptor-1.
Br J Haematol
; 101(1): 78-81, 1998 Apr.
Article
em En
| MEDLINE
| ID: mdl-9576186
ABSTRACT
The platelet-type thrombin receptor was the first member to be identified in a family of protease activated receptors (PARs) and has been designated PAR-1. We recently reported that the large granular lymphocytes (LGLs) in patients with proliferations of CD8+ cells co-expressed PAR-1 and the expression of PAR-1 correlated with the expression of CD57. Here we show, by three-colour immunofluorescence, that the LGLs from a patient with a rare CD4+ CD57+ monoclonal expansion also expressed PAR-1. Northern blot analysis confirmed the presence of high levels of mRNA for PAR-1 in these LGLs.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos CD4
/
Receptores de Trombina
/
Granulócitos
/
Linfocitose
Tipo de estudo:
Prognostic_studies
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Br J Haematol
Ano de publicação:
1998
Tipo de documento:
Article