NMDA receptor-mediated oscillatory activity in the neonatal rat spinal cord is serotonin dependent.
J Neurophysiol
; 79(5): 2804-8, 1998 May.
Article
em En
| MEDLINE
| ID: mdl-9582246
ABSTRACT
The effect of serotonin (5-HT) receptor blockade on rhythmic network activity and on N-methyl--aspartate (NMDA) receptor-induced membrane voltage oscillations was examined using an in vitro neonatal rat spinal cord preparation. Pharmacologically induced rhythmic hindlimb activity, monitored via flexor and extensor electroneurograms or ventral root recordings, was abolished by 5-HT receptor antagonists. Intrinsic motoneuronal voltage oscillations, induced by NMDA in the presence of tetrodotoxin (TTX), either were abolished completely or transformed to long-lasting voltage shifts by 5-HT receptor antagonists. Conversely, 5-HT application facilitated the expression of NMDA-receptor-mediated rhythmic voltage oscillations. The results suggest that an interplay between 5-HT and NMDA receptor actions may be critical for the production of rhythmic motor behavior in the mammalian spinal cord, both at the network and single cell level.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Relógios Biológicos
/
Serotonina
/
Receptores de Serotonina
/
Receptores de N-Metil-D-Aspartato
/
Atividade Motora
Limite:
Animals
Idioma:
En
Revista:
J Neurophysiol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Canadá